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Acquired non-inflammatory myopathy (ANIM) is a neurological disorder primarily affecting skeletal muscle, most commonly in the limbs of humans, resulting in a weakness or dysfunction in the muscle.〔 A myopathy refers to a problem or abnormality with the myofibrils, which compose muscle tissue. In general, non-inflammatory myopathies are a grouping of muscular diseases not induced by an autoimmune-mediated inflammatory pathway. These muscular diseases usually arise from a pathology within the muscle tissue itself rather than the nerves innervating that tissue. ANIM has a wide spectrum of causes which include drugs and toxins, nutritional imbalances, acquired metabolic dysfunctions such as an acquired defect in protein structure, and infections. Acquired non-inflammatory myopathy is a different diagnosis than inflammatory myopathy. Inflammatory myopathies are a direct result of some type of autoimmune mediated pathway whereas ANIM is not the result of a dysfunction of the immune system.〔 In addition, the cause of inflammatory myopathy is relatively unknown, whereas many causal agents for ANIM have been discovered which typically affect the structural integrity and function of the muscle fibers.〔 Most myopathies are typically first diagnosed and classified as an idiopathic inflammatory myopathy.〔 However, a diagnosis of ANIM occurs when the cause of the myopathy is found to not arise from an autoimmune mechanism.〔 ==Symptoms== Patients with acquired non-inflammatory myopathy typically experience weakness, cramping, stiffness, and tetany, most commonly in skeletal muscle surrounding the limbs and upper shoulder girdle.〔 The most commonly reported symptoms are: *Muscle fatigue〔 *Pain〔 *Muscle spasms and cramps *Tingling *Numbness *Tetany〔 *Loss of coordination and balance〔 *Lack of fine and gross motor control〔 *Muscular wasting and atrophy〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Acquired non-inflammatory myopathy」の詳細全文を読む スポンサード リンク
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